Serum free light chains; the need to establish local reference intervals
نویسندگان
چکیده
منابع مشابه
Are renal reference intervals required when screening for plasma cell disorders with serum free light chains and serum protein electrophoresis?
Renal impairment and polyclonal hypergammaglobulinemia may abnormally increase the serum free light chain (sFLC) ratio, giving false-positive results with current reference intervals. We measured sFLCs with concomitant serum protein electrophoresis (SPEP) and urine protein electrophoresis (UPEP) in 281 patients. Results were interpreted relative to renal function (serum creatinine concentration...
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under usual artificial light conditions, and storage of unproc-essed whole blood without antico-agulants at room temperature on the bench. Additionally, we tested the effect of multiple freeze-thaw cycles. 25(OH)–vitamin D 3 measurements were performed on a Cobas E601 an-alyzer (Roche), using the vitamin D 3 (25-OH) assay as recommended by the manufacturer. Samples from each storage experiment ...
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To the Editor: We read with interest the recent paper on the combination of serum protein electrophoresis (SPEP) and serum free light chain (FLC) assay as a potential alternative to SPEP and urine protein electrophoresis (UPEP) screening for paraproteinemia (1 ), as well as the accompanying editorial on sensitivity and specificity issues of the serum FLC assay (2 ). This assay, which first beca...
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Employment or Leadership: None declared. Consultant or Advisory Role: F.C. Wu, Organon International, Bayer Schering Pharma, Eli Lilly, Proctor & Gamble, Pierre Fabre Medicaments, Ferring Pharmaceuticals, TAP Pharmaceuticals, Ardana Bioscience, and GlaxoSmithKline. Stock Ownership: None declared. Honoraria: F.C. Wu, Organon International, Bayer Schering Pharma, Lilly ICOS, Ardana Bioscience, an...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 2007
ISSN: 0004-5632,1758-1001
DOI: 10.1258/000456307782268200